ABSTRACT
Dose-response relationship is the association between the dose administered and the response/s that is/are exhibited. Response/s and dose are causally related (Eaton and Klaassen, 1996). Establishing a causeresponse relationship is very important in the analysis/assessment of a risk (Christensen et al., 2003). Though the terms ‘dose’ and ‘dosage’ refer to more or less a same thing, there is a difference between these two terms. Dose refers to a stated quantity or concentration of a substance to which an organism is exposed and is expressed as the amount of test substance per unit weight of test animal (example, mg/kg body weight), whereas dosage is a general term comprising the dose, its frequency and the duration of dosing. Dosages often involve the dimension of time (example, mg/kg body weight/day) (Hayes, 1991).
