ABSTRACT
Pathology occupies a pivotal role in animal experiments. The toxicity of a compound can be assessed by linking compound-related changes in biochemical, haematological or urinalysis parameters with organ weight, gross pathology and/or histopathological changes (Tyson and Sawhney, 1985; Krinke et al., 1991). All regulatory guidelines on animal experiments have given special emphasis to pathology. For example, in the long-term repeated dose administration studies, it is a regulatory requirement that all data relating to moribund or dead animals as well as the results of postmortem examinations is scrutinized and the analysis of the cause of individual deaths is done (OECD, 2000).
