This chapter is focused on the recent strategies developed to create multicomponent dumbbell and core-shell nanohybrids that yielded from the combination of different single-nanoscale components via seed-mediated methods. Further controlling the heterogeneous growth of multicomponent nuclei by adjusting the synthetic parameters, leading to the desired morphology of the ϐinal dumbbells and core-shells nanohybrid products is discussed. Nanohybrids with their unique features and multifunctional properties due to the interplay between their structure, morphology, and composition are brieϐly presented. The catalytic activity of these nanohybrids for low temperature CO catalytic oxidation is also highlighted.