ABSTRACT
There is a positive correlation between the number of neurofibrillary tangles and neuritic plaques, on the one hand, and, on the other, the degree of cognitive impairment.
Histological changes seen commonly in the hippocampus include:
∑ granulovacuolar degeneration ∑ Hirano bodies ∑ neurofibrillary tangles ∑ neuritic plaques (senile plaques).
