ABSTRACT
The pathologic hallmark of sarcoidosis is discrete, compact
non-caseating granulomas. The granulomas comprise mainly
epithelioid cells with CD4 lymphocytes, mature macrophages
and multinucleated giant cells interspersed throughout the
epithelioid core and CD8 lymphocytes in the periphery. The
granulomatous inflammation leads to distortion of local
architecture, tissue injury and fibrosis.