ABSTRACT
The diagnostic granuloma that forms after the intradermal
injection of sarcoidosis tissue is named after the Norweigen
pathologist Ansgar Kveim who first formally reported in 1941
that the injection of a heated suspension of sarcoid lymph node
tissue caused a nodule to develop at the site of injection in 12
out of 13 patients with sarcoidosis (Kveim 1948). The reaction
occurred between nine days and four weeks after injection and
subsequent biopsy of the nodule revealed histological changes
consistent with sarcoidosis. The reaction was not seen in an
equivalent number of control patients without the disease.
