ABSTRACT
The lung is the most frequently affected organ in patients
with sarcoidosis (Scadding 1961; Mitchell et al. 1977; Neville
et al. 1983; Hillerdal et al. 1984; Baughman et al. 2001).
Pulmonary sarcoidosis exhibits a wide range of clinical and
radiological phenotypes. The most frequent of these is
a predominantly bronchocentric, and often self-limiting,
granulomatous inflammation. Up to 10 percent of patients
however, even at first presentation have irreversible fibrotic or
fibrobullous change (Scadding 1961; Baughman et al. 2001).
This is generally associated with ongoing granulomatous
inflammation. Furthermore, as many as 1020 percent of the patients who present with initially inflammatory lesions
alone subsequently develop chronic disease that progresses
to fibrosis.
