ABSTRACT
The aim of treatment is to reduce the number of any residual malignant cells and to permit engraftment of the re-infused donor marrow or stem cells. For tumour control, the total dose of radiation should be as high as possible within the limits of normal tissue tolerance. Ease of engraftment is related to the type of marrow or stem cells infused. Less immune suppression is needed when the patient’s own cells are re-infused than when fully compatible donor cells are used. High doses of TBI appear to facilitate engraftment of cells that are not fully compatible, although this type of procedure is less commonly used now.
