ABSTRACT

Thrombophilia is an abnormality of haemostasis predisposing to thrombosis. It may be:

hereditary:

activated protein C resistance (associated with factor V Leiden mutation)

protein C deficiency

protein S deficiency

antithrombin deficiency

prothrombin gene mutation

acquired:

antiphospholipid syndrome

polycythaemia

other conditions (e.g. malignancy)