ABSTRACT
This chapter presents the case study of a 37-year-old man. A 37-year-old man presents with a rash and diarrhoea to the haematology out-patient team. He had developed red patches on his skin, which then became pale and gradually felt firm and tight. He describes stiffness of his elbow and knee joints, such that he is having trouble straightening his limbs. He is taking multiple medications including aciclovir, co-trimoxazole, penicillin V, itraconazole and omeprazole. He had undergone a matched, unrelated, allogenic bone marrow transplant for acute myeloid leukaemia. Graft-versus-host disease (GVHD) is an immune disorder that may occur after bone marrow transplantation. GVHD is an immune disorder that commonly follows bone marrow transplantation. GVHD may also affect the eyes, mouth, joints, gastrointestional tract, liver and respiratory system. Prevention of GVHD is the mainstay of treatment. Chronic GVHD carries a high morbidity and mortality.
