ABSTRACT
Multiple sulfatase deficiency was reported in 1965 by Austin, Armstrong and Shearer [1,2] as metachromatic leukodystrophy (MLD) in which there were also features of mucopolysaccharidosis. Deficient activity of a number of sulfatases led to the designation of multiple sulfatase deficiency (MSD) [3]. At least seven enzymes are now known to be deficient [2-5].
