ABSTRACT
Adenylosuccinate lyase (ASL) deficiency was first described by Jaeken and Van den Berghe [1] in 1984. This created enormous interest because autistic behavior was observed in the affected patients in this family, and it would be of considerable interest if it were possible to relate molecular changes in the gene for ASL to the genetics of autism [2]. However,
extensive survey of autistic populations has failed to turn up additional patients with lyase deficiency.
