ABSTRACT
Hyphenated NMR instruments have evolved to include a number of automated operation modes for sample collection and detection. These LC-NMR modes consist of, but are not limited to, continuous flow, stopped flow, loop collection, and solid-phase extraction (SPE) [1]. As noted previously, LC peaks of interest for the NMR transfer require the use of a non-NMR detector. Detection systems such as UV, DAD (diode array detector), and MS are compatible with the gradient LC methods that are required to keep the eluting peaks as sharp as possible. For flow methods, this is critical in preserving NMR sensitivity.
