ABSTRACT
Disaccharides Produced by Solvolysis ....................................................................... 72 6.7 Capillary Electrophoresis ....................................................................................................... 73 6.8 Gas Chromatography/Mass Spectroscopy .............................................................................. 73 6.9 Fourier Transform Infrared Spectroscopy .............................................................................. 74 6.10 Nuclear Magnetic Resonance Spectroscopy ........................................................................... 74 6.11 Procedures Used for the Analysis of Biological Samples ...................................................... 74 6.12 Application of Cationic Dyes.................................................................................................. 74 6.13 Electromigration Methods ...................................................................................................... 75 6.14 Fluorophore-Assisted Carbohydrate Electrophoresis ............................................................. 76 6.15 Chromatographic Methods ..................................................................................................... 76
6.15.1 High-Performance Liquid Chromatography Analysis ................................................77 6.15.2 Mass Spectrometry and Hyphenated Techniques ....................................................... 78 6.15.3 Electrospray Ionization-Mass Spectrometry-High-Performance Liquid
Chromatography ......................................................................................................... 78 6.15.4 Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry-High-
Performance Liquid Chromatography ........................................................................ 79 6.16 Solid-Phase Assays, Enzyme-Linked Immunosorbent Assays, and ELISA-Like
Techniques .......................................................................................................................... 79 6.17 Conclusions .............................................................................................................................80 References ........................................................................................................................................ 82
Chondroitin has been widely used over the last 20 years as a nutraceutical and pharmaceutical supplement, predominantly for the treatment of osteoarthritis and rheumatoid arthritis, although new therapeutic applications are being investigated, for example, in the eld of allergy. In response to this demand, new commercial sources are being developed and new analytical procedures devised for monitoring raw materials, formulated products, and biological uids.
