Skin plays an important role in body protection. The primary function of skin is to protect body from damage and provide a barrier between the internal and external environments. The skin also as physiological barrier against infection by pathogens as an innate immune defense (Madison 2003; Proksch, Brandner, and Jensen 2008). The skin is the largest and most exposed organ of the body, which greatly increases its risk of getting disease or complications. For this reason, skin diseases occur more frequently than any other diseases.