ABSTRACT
Generally, glucosamine is produced from glucose inside the cell through the hexosamine biosynthetic pathway. Under normal physiological conditions, glucosamine levels in the extracellular fluids are below detection, but if provided in the diet, it is rapidly taken up into cells by glucose transporters,[3,4] and is phosphorylated to produce glucosamine-6-phosphate, which enters the hexosamine biosynthetic pathway as such (see Fig. 2 for details).
