ABSTRACT
Finely tuned spatiotemporal calcium events are a highly conserved and ubiquitous mode for the control of biochemistry and physiology in almost all eukaryotic cells [35, 40, 86]. Endothelial cells (ECs) are no exception, and intracellular calcium serves as a positive or negative regulatory signal for a wide range of cell functions, including survival, proliferation, motility, apoptosis, and differentiation [34, 36, 276]. A broad number of calcium-dependent enzymes are also associated with the progression through the cell cycle (the exit from quiescence in early G1 phase, the G1/S transition and other checkpoints during S and M phases [22, 204, 280]), and mediate the activation of several nuclear factors involved in the DNA division machinery, for example cdk and cyclins [108, 130, 340].
