ABSTRACT
NICHOLAS BODOR and THORSTEINN LOFTSSON* / University of Florida, Gainesville, Florida
I . In t roduct ion 337
I I . P rod rugs 339
I I I . Classical P r o d r u g s as Chemical Delivery Systems 340
IV. Susta ined Chemical Delivery Systems 342
V. Sus ta ined Delivery of Natural Soft Drugs 343
VI. Brain,-Specific Susta ined Chemical Delivery Systems 357
VII . Conclusions 368
References 369
I. INTRODUCTION
Optimization of d r u g del ivery by means of chemical modifications of known d r u g s or thei r analogs has gained increas ing in t e r e s t d u r i n g recent y e a r s . Commonly two general approaches have been used to
*On leave of absence from the Univers i ty of Iceland, Rekjavik, Iceland.
