ABSTRACT
VINCENT H. K. LI and JOSEPH R. ROBINSON / Universi ty of Wisconsin , Madison, Wisconsin
VINCENT H. L. LEE / Universi ty of Southern California, Los Angeles , California
I . In t roduct ion 4
II . Terminology 5
I I I . Rationale of Susta ined/Control led D r u g Delivery 7
IV. Factors Influencing the Design and Performance of Susta ined/Control led Release Products 9
V. Physicochemical Proper t i es of a D r u g Influencing Design and Performance 12
A. Aqueous Solubility 13 B . Part i t ion Coefficient and Molecular Size 14 C. D r u g Stability 14 D . Protein Binding 15
VI. Biological Factors Influencing Design and Performance of Susta ined/Control led Release Produc ts 15
A. Absorption 16 B . Dis t r ibut ion 18 C. Metabolism 23 D . Duration of Action 26 E. Side Effects 30 F . Margin of Safety 31
G. Role of Disease State 33 H. Role of Circadian Rhythm 35
VII . Selected Routes of D r u g Administration 36
VIII .
