- Principles of Pharmacology and Toxicology
DOI link for - Principles of Pharmacology and Toxicology
- Principles of Pharmacology and Toxicology book
The past century has seen a tremendous expansion in the number of synthetic chemicals employed by humankind as materials, drugs, preservatives for foods and other products, pesticides, cleaning agents, and even weapons of war. The American Chemical Society maintains a chemical registry. Since 1907, it has recorded 33 million organic and inorganic substances and 58 million sequences as of 2008. About 4000 new chemicals are added each day. A study by the Danish Environmental Protection Agency calculated that 13.4% of them possess acute toxicity, 2.5% reproductive toxicity, 3.9% are mutagens, 1.8% carcinogens, and 3.5% are dangerous to the aquatic environment. Four thousand chemicals are used as medicinals and at least 1200 more as household products. Add to this the numerous natural substances, both inorganic and organic, that possess toxic potential, and it is little wonder that the public expresses concern and even, sometimes, panic about the harmful effects these agents may exert on their health and on the environment. Tens of thousands of these agents have never been subjected to a thorough toxicity testing.