ABSTRACT
Over the last century, the wide use of heavy metals has increased both environmental pollution and the number of harmful effects for human beings (Manaham, 1994).
Direct contact with transition metals such as nickel, cobalt, chromate, palladium, platinum, gold, mercury, etc. frequently occurs in either domestic or industrial settings, and is difficult for everyone to avoid. Since the skin is one of the largest organs that function as structural interface between body and its environment, it becomes one of the main targets of the action of metals.
