ABSTRACT
Genetic manipulation of cells and tissues shows enormous promise for correcting a myriad of metabolic disorders. Many of the concerns about this medical approach arise from strategies in which permanent genetic alterations are made in the target cell. Gene therapy of wounds, on the other hand, can be in the form of gene medicine, in which short-term and/or highly regulated expression occurs from genes specifically targeted to the wound site. Given the local and transitory nature of the wound, gene medicine has the potential to fulfill several unmet needs in wound care.
