Cholestatic Liver Disease: Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and AIDS-Associated Cholangiopathy Keith D. Lindor, MD

Cholestatic liver disease in adults without biliary obstruction encompasses a broad differential diagnosis. Drug-induced cholestasis may be the most common explanation for cholestasis in these patients. Primary biliary cirrhosis is the most common cholestatic liver disease in adults. Primary sclerosing cholangitis is about half as common as primary biliary cirrhosis. Other cholestatic conditions in adults include autoimmune cholangitis (sometimes known as antimitochondrial antibody [AMA]-negative primary biliary cirrhosis), acquired immunodeficiency syndrome (AIDS)-associated cholangiopathy, and miscellaneous conditions.