ABSTRACT
Prostate cancer in men is the most commonly registered new malignant diagnosis and the second most commonly registered cause of cancer-related death in some countries. The specific causes of prostate cancer initiation and progression are not known, however, both genetics and the environment seem to play a significant role. It is accepted that prostate cancer develops and initially progresses slowly yet patients with metastatic, androgen-independent prostate cancer currently have few therapeutic options and their prognosis is bleak. The slow growth of prostate cancer and the discrepancy between the frequency of “latent” and clinically manifest disease suggest many factors may have a role in controlling the progression of this disease.
