ABSTRACT

Cell death, in a dynamic balance with cell proliferation, is necessary to maintain homeostatic control of cell numbers,1 with 10 billion cells dying in an average adult every day, simply to keep balance with the numbers of new cells arising from the body’s stem cell populations. Cell death occurs principally as a result of damage, but it also occurs under controlled conditions, such as in the sculpturing of organs in an embryo and the elimination of T cells once they have fought an infection.