ABSTRACT
Aesthetic skin rejuvenation (ASR) is certainly not a
new process, and historical accounts date back as many
as four millennia (2000 BC). For thousands of years,
humans (both male and female) have been utilizing
treatments to improve the appearance of a poor com-
plexion or to enhance the beauty of a natural complex-
ion. Throughout the ages, humans have sought out
simple, elective cosmetic methods to improve highly
visible and undesirable permanent cutaneous signs:
facial wrinkles and residual facial scars that may follow
ailments such as acne, smallpox, and chickenpox. 1 The
first examples of such ‘treatments’ were apparently
noted in ancient Egypt and recorded in the famous
Edwin Smith Surgical Papyrus, the oldest medical doc-
ument in existence. 2 The description of the wrinkle-
removal recipe prepared from hemayet fruit included
the composition and the technique for application.
