ABSTRACT
Cholinergic afferents innervate the cerebral cortex during the most dynamic periods of neuronal differentiation and synapse formation, suggesting they play a regulatory role in these events.32 Disruption of cholinergic innervation during early postnatal development (e.g. neonatal basal forebrain cholinergic lesions in rats) results in delayed cortical neuronal development and permanent changes in cortical cytoarchitecture and cognitive function.32
