ABSTRACT

Lipid molecules constitute 50% of the mass of most animal cell membranes (Alberts et al. 2002). The plasma membrane can consist of more than 2000 different species of lipid (Barenholz 2000; Dart 2011). The most abundant membrane lipids are the phospholipids, including phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylcholine (PC), and sphingomyelin (Alberts et al. 2002). Cholesterol and glycolipids are also important membrane lipids. Cholesterol, sphingolipids, and phospholipids can form specialized domains such as lipid “raft” (Simons and

5.1 Introduction ............................................................................................................................77 5.2 Ion Channels in the Heart: Ion Channels in Cardiac Myocytes and Fibroblasts ...................80