ABSTRACT

Hyaluronan (HA, Figure 1) is a linear polysaccharide consisting of repeating disaccharide units of β-1,3-N-acetyl-D-glucosamine and β-1,4-D-glucuronic acid. The HA molar sizes in the human organism vary between 2 × 105 and 10 × 106 Da. An adult person weighing 70 kg has about 15 g of HA in the body, yet about one-third of this amount turns over daily.