ABSTRACT
Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University,
3303 SW Bond Ave, Portland, OR
Ruikang K. Wang
Biophotonics and Imaging Laboratory, Department of Bioengineering, University of Washington,
Seattle, WA
10.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
10.2 Optical Microangiography (OMAG) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
10.3 Applications of OMAG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
10.4 Ultra High Sensitive OMAG (UHS-OMAG) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 408
10.5 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 414
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 416
Optical microangiography (OMAG) is a recently developed volumetric imaging technique based
on coherence domain imaging modality, which is capable of producing 3-D images of dynamic
blood perfusion within microcirculatory tissue beds in vivo. In this chapter, we will discuss its basic
principle of operation, theoretical overview, extended functionalities, and its applications in various
clinical and fundamental research fields. In addition, we will also review the principle of operation,
latest technological developments and applications of ultra high sensitive OMAG, an extended ver-
sion of OMAG for high sensitive imaging of very slow flow in capillary beds.
