ABSTRACT
The idea for targeted chemotherapy of diseases has been proposed in the 19th century by the German scientist Dr. Paul Ehrlich (1854-1915), a Nobel laureate (in 1908) for achievements in immunology (Krause 1999; Tan and Grimes 2010; Turk 1994). He is noted also for his contributions in histology, treatment of infectious diseases, and discovering Salvarsan 606-the rst drug targeted against a specic pathogen (trypanosome, which causes syphilis) (Gensini et al. 2007; Kaufmann 2008). Dr. Ehrlich popularized the concept of a “magic bullet”—a compound that could selectively target a disease-causing organism conjugated with a toxin for that organism; then, the toxin could be delivered along with the agent of selectivity, and this magic bullet would kill only the targeted organism (Winau et al. 2004). Nowadays, about a century later, this concept became the main aim of nanomedicine that emerged from the
1.1 Introduction ......................................................................................................3 1.2 Interactions of Colloidal Drug Carriers with Proteins and Cells .....................5
