ABSTRACT
Carcinogenesis is a complex, multistage process that impacts hundreds of genes and gene products that are critical in the regulation of a multitude of cellular functions. A major focus of much of our work over the past decade has been the elucidation of molecular and cellular mechanisms and targets essential in cancer prevention. An important outcome of these investigations is the clarication of signal transduction pathways induced by a variety of tumor promoters in cancer development. A prevailing idea today is that cancer might be prevented (Bode et al. 2009a) or treated by using small molecules to target specic and, perhaps, multiple cancer genes, signaling proteins, and transcription factors. Each stage of cancer development could be a potential target for anticancer agents, especially the promotion stage. Importantly, new cutting-edge technologies, including supercomputer in silico screening and protein simulation and modeling, not only are rapidly clarifying the
5.1 Introduction ............................................................................................................................ 81 5.2 Tea, Coffee, and Cocoa as Anticancer Agents ....................................................................... 83
5.2.1 Protein Targets of Epigallocatechin Gallate ............................................................... 83 5.2.2 Anticancer Activities and Molecular Targets of Coffee and Cocoa Phytochemicals .... 91
5.3 Molecular Targets of Resveratrol ...........................................................................................92 5.4 Protein Targets of [6]-Gingerol...............................................................................................93 5.5 Anticancer Targets of Selected Flavonoids and Other Polyphenol Compounds ....................94
