ABSTRACT

Foodstuff ............................................................................................................................... 275 7.5 Thiamine Biosynthesis, Degradation, and Regulation by Riboswitches .............................. 276 7.6 Metabolism and Distribution of Thiamine Derivatives ........................................................ 277

7.6.1 Mechanisms of ThDP Synthesis ............................................................................... 277 7.6.2 Mechanisms of ThTP Synthesis ............................................................................... 278

7.6.2.1 Possible Involvement of a ThDP:ATP PhosphotransferaseHypothetical Implication in Leigh’s Disease ............................................. 278

7.6.2.2 ThTP Synthesis by Adenylate Kinases ...................................................... 279 7.6.2.3 ThTP Synthesis by a Chemiosmotic Mechanism ......................................280