Diverse Roles of Angiotensin Receptor Intracellular Signaling Pathways in the Control of Water and Salt Intake

Angiotensin II (AngII) is a key component in the maintenance of body uid homeostasis. It has potent dipsetic* and natriorexigenic effects when injected into the brain of rats. This ingestive response to AngII is so reliable that AngII is frequently used to verify proper placement of cannulae in forebrain ventricles, even by laboratories with little interest in uid intake. The actions of AngII have been an important focus in the study of uid intake, but have also been particularly informative in other elds of study. Much of our knowledge about the means by which peripherally derived

5.1 Introduction .................................................................................................... 89 5.2 Angiotensin Receptor Structure and Signaling .............................................. 91 5.3 Divergent Behavioral Relevance of Angiotensin Receptor Signaling

Pathways .........................................................................................................92 5.4 Diverse Roles of Angiotensin Receptor Signaling Pathways in the

Control of Water Intake ..................................................................................94 5.5 Conclusions .....................................................................................................97 Acknowledgments ....................................................................................................98 References ................................................................................................................99