ABSTRACT
MDM2 and Parc ...............................................................................294 13.3.4 Mitochondrial Action of p53: Interaction with Bcl-2 Family
Members and MOMP ....................................................................... 295 13.4 Involvement of NO/sGC/cGMP/PKG Signaling Pathway in the
Regulation of CDDP Sensitivity in Ovarian Cancer .................................... 295 13.4.1 NO/sGMP/PKG Pathway .................................................................. 295 13.4.2 Activation of PKG-Iα and PKG-Iβ Isoforms Depends on the
Levels of Endogenous NO ................................................................296 13.4.3 Activation of PKG-Iα and Src in Ovarian Cancer ............................296 13.4.4 Involvement of NO/sGC/cGMP/PKG Signaling Pathway
and p53 Regulation in CDDP Sensitivity .........................................296 13.5 Role of Akt and mTOR in CDDP Chemoresistance in Ovarian Cancer ......297
