ABSTRACT

The advent of rapid medical advance has brought with it a myriad of positive impacts, not the least of which is a dramatic increase in average life expectancy, primarily among those living in developed countries. However, as the average age of the population increases, new problems have arisen such as a corresponding

10.1 The Pathological Basis of Neurodegeneration .............................................. 279 10.1.1 Role of Oxidative Stress in Neurodegeneration ................................280 10.1.2 Role of Excitotoxicity in Neurodegenerative Disease ...................... 282 10.1.3 Role of Neuroinammation in Neurodegeneration .......................... 283 10.1.4 Role of Apoptosis in Neurodegeneration ..........................................284

10.2 Anthocyanin Absorption and Blood-Brain Barrier Permeability ................287 10.3 Anthocyanins as Novel Neuroprotective Agents ..........................................288