ABSTRACT
Tissue engineering requires the cells to have regenerative potential when seeded on three-dimensional networks that are implanted into the defect. Various synthetic and other biopolymers are used to construct scaffolds for tissue engineering applications (Bartold et al. 2006). The emerging eld of regenerative medicine tries to nd solutions for the incomplete regeneration of tissues in the human body. It employs living cells, biomaterials, soluble mediators of tissue regeneration, or a combination of these to recapitulate normal tissue structure and function (Nerem 1991; Marler et al. 1998; Vacanti and Langer 1999). The National Institute of Biomedical Imaging and Bioengineering (NIBIB) (https://www.nibib1.nih.gov/) denes tissue engineering as “a rapidly growing area that seeks to create, repair and/or replace tissues and organs by using combinations of cells, biomaterials, and/or biologically active molecules.” Various techniques, such as phase separation, self-assembly, and electrospinning have been developed to fabricate nanobrous scaffolds with unique properties. Among these techniques, electrospinning technology has become popular for the fabrication of tissue engineering scaffolds in recent years because it is a simple, rapid, efcient, and inexpensive method for producing nanobers by applying a high voltage to electrically charged liquid (Huang et al. 2003; Zhang et al. 2007; Teo and Ramakrishna 2009).
