ABSTRACT

As man has learned more about the structure of the human genome, its command and control pathways, and the genomes of other animals, plants, bacteria and yeasts, he has also learned how to manipulate DNA and mRNA, including the insertion of recombinant genes into existing genomes. As our understanding of the human genome has expanded, so has our realization that many human diseases, conditions, and predispositions to disease are correlated with mutations of specic structural and regulatory genes.