ABSTRACT
Although the great majority of pKa measurements have been carried out in aqueous solutions, a significant number of measurements have been made in other solvents, and findings in these solvents can be highly informative regarding the inherent nature of the dissociation process as well as of practical importance because of the common use of nonaqueous solvents in organic chemistry and industry. How the solvent environment modifies the intrinsic gas-phase acid dissociation is a feature of fundamental importance, and can lead to a broader understanding of the ionization process.
