ABSTRACT

We will now see how Ca2+ induces these and other varied metabolic responses, and how another second messenger, inositol triphosphate (IP3), which often mediates this rise in Ca2+, is generated and functions. Still another second messenger, diacylglycerol (DG), which is formed from the same precursors as IP3, is used to regulate other cell functions through activation of protein kinase C (PKC). All these second messengers interact in complex circuits to regulate crucial aspects of the growth, metabolism, and death of cells (Ch. 4).