ABSTRACT
MRI techniques, including relaxation, perfusion, and diffusion magnetic resonance imaging (MRI), have provided tremendous insights about ischemic tissue injury. Particularly, the adoption of perfusion and diffusion MRI in the acute stroke setting has allowed noninvasive demarcation of ischemic tissue for MRI-guided stroke therapy. The imaging denition of penumbra continues to evolve, aided by emerging MRI indices including cerebral metabolic rate of oxygen (CMRO2), tissue acidosis, and diffusion kurtosis that are promising to improve individualized stroke treatment. In this chapter, we briey summarize MRI methods in preclinical stroke models that upon validation may eventually transform stroke imaging in the clinical setting of acute stroke.
