ABSTRACT
The human brain possesses the ability to adapt in response to anatomical change (e.g., healthy aging) that has been labeled neuroplasticity. It is important at all stages of life but is critical in neurological disorders such as stroke. This chapter focuses upon our new understanding of mechanisms underlying functional decits after adult-onset stroke. I review the interactions between different brain regions that may contribute to motor disability after stroke. New information now points to the involvement of nonprimary motor areas and their interaction with the primary motor cortex as areas of interest. In the future, this work may produce a tailored rehabilitation program for each patient in order to maximize his or her recovery.
