ABSTRACT
In humans, ArA is derived from dietary linoleic acid, or is ingested as a dietary constituent and is then incorporated into membrane phospholipid. Normally, the concentration of free ArA (and other 20-carbon PUFAs) in the cell is very low, but it is released in response to widely divergent physical, chemical, and hormonal stimuli. The biosynthesis of eicosanoids depends primarily on the availability of free 20-carbon PUFAs.
