ABSTRACT
The uniqueness of each person’s genetic makeup suggests that each of us may have differences in metabolism and nutritional needs and responses. These are often obvious where enzyme dežciency occurs but more subtle where the properties of an enzyme are only slightly altered. Because proteins are complex structures subject to a variety of alterations ranging from absence to alleles, which cause no phenotypic change, there is often a wide range of severities for a particular genetic disease. Many genetic diseases are silent until elicited by an environmental factor. This chapter focuses on those situations where diet in˜uences genetic disease or where nutritional therapy is useful.
