This chapter presents a general overview of regulatory toxicology primarily related to the United States and the European Union (EU). More detailed information on regulations and guidelines related to speci˜c types of products and areas of toxicology can be found in other chapters in this book as outlined in Table 23.1. Much of the information presented in this chapter was consolidated from several chapters in the second edition of the Handbook of Toxicology

authored by the following individuals: Michael J. Derelanko (US Overview), Henry C. Fogle (US EPA/Chemicals [TSCA]), Jane E. Harris (US EPA/Pesticides [FIFRA]), Steven J. Hermansky (Medical Devices), and Dennis J. Naas (Consumer Products). Regulatory laws, regulations, and guidelines frequently change. Therefore, it is important for the reader to verify that any regulatory information provided in this book is still applicable for his/her current and future situation and needs.