ABSTRACT
The central dogma of molecular biology is that the genetic information stored in DNA is used to produce mRNA molecules during transcription, which can then be translated into proteins during translation. The main actors of these two fundamental steps are RNA polymerases and ribosomes. The biochemical processes involved are highly complex, and our present understanding does not permit efficient mathematical modelling. The literature proposes extremely simplified mathematical models which permit us, however, to get insight on cellular processing; see, e.g., [98] where a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium provides information on previously unobserved cellular behaviours.
