ABSTRACT
Over the past 50 years, the understanding of type 1 and type 2 diabetes has changed drastically. In the 1970s, medical schools were teaching that type 2 diabetes was due to the aging of the beta cell somehow and that it was otherwise analogous to type 1 diabetes where the most important element would be the control of blood sugar. With the discovery of the immune actions of adipocytes in abdominal obesity, the role of inammation in type 2 diabetes mellitus (T2DM) became evident as discussed in this chapter.
