ABSTRACT
Inammation is a key mechanism in the development of chronic kidney disease (CKD). Severe acute or chronic inammation can initiate, maintain, and promote progression of CKD. Inammation in CKD results from an imbalance of proin-ammatory and proresolving mediators that determine the extent of activity of the inammatory response. The regulation of this system is complex, but several key immune cells, with macrophages being of particular importance, are major modulators of the inammatory response in CKD.
