In this paper, we rst present a brief review of the tissue engineering of reconstructed skin models and SOC, followed by an overview of the commercially available ones. We then presented several examples of studies carried out to determine the benets of active ingredient targeting some aging features as well as effects of UVB-UVA irradiation as an inducer of oxidative stress and photoaging. This overview is then followed by an in-depth focus on UV-induced damages and photoprotection assessed on both RHS and SOC. Finally, studies performed to monitor the pigmentation process in a pigmented skin model are also discussed.