ABSTRACT

3.1 Quantitative Trait Locus (QTL) Based on Sibpairs

Many genetics books, especially in the field of biology or molecular genetics, tend to trace the origin of modern genetics to Mendel's experiments in the 1860s. However, at almost the same time, F. Galton started his work on quantitative genetics, mainly using the stature of human beings (Galton, 1889). Apparently, he noticed that height was inheritable, but the pattern on how stature is inherited is much less clear-cut than Mendel's sweet pea characteristics. Galton, Karl Pearson and their students developed their theory by using correlation and linear model such as